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Carl A. Hubel, Ph.D.
Associate Investigator, Magee-Womens Research Institute
Associate Professor, Obstetrics, Gynecology and Reproductive Sciences, and Environmental and Occupational Health, University of Pittsburgh
Ph.D., University of Vermont, 1988
Postdoctoral Associate, University of Vermont, 1988-1989
Postdoctoral Fellowship, University of Cincinnati, 1991-1993
Postdoctoral Fellowship, Magee-Womens Research Institute, Pittsburgh, PA, 1993-1996
Research Interests
Epidemiological studies have recently demonstrated a relationship between preeclampsia and later-life coronary heart disease. Dr. Hubel is testing the hypothesis that pregnancies complicated by preeclampsia may identify women at risk of vascular disease in later life and may provide the opportunity for lifestyle and risk factor modification to alter vascular disease risk. He has found evidence of altered lipid metabolism, insulin resistance, and imbalances in angiogenic factors in postpartum women with a history of preeclampsia. Such findings may help to explain the increased cardiovascular risk in women who have had preeclampsia.
Dr. Hubel and colleagues were the first to formally propose that oxidative stress is a key factor in the progression of preeclampsia. Human and animal studies have affirmed this link (Bilodeau and Hubel, 2003). Plasma vitamin C (ascorbate) concentrations are decreased in women with preeclampsia and rates of ascorbate oxidation are increased in the blood of these women (Hubel et al., Free Radic Biol Med, 1997). Current work is directed at identifying the reasons for ascorbate depletion in women with preeclampsia.
New research tests the hypothesis that increased mobilization and activity of maternal, bone marrow-derived endothelial progenitor cells contributes to the adaptive cardiovascular changes of normal pregnancy and that dysfunction of these cells contributes to the pathogenesis of preeclampsia.
Selected Publications
Hubel CA, Snaedel S, Geirsson RT, Roberts JM, Ness RB, Arngrímsson R. Dyslipoproteinemia in postmenopausal women with a history of eclampsia. Br J Obstet Gynecol, 107:776-784, 2000.
Ramirez RJ, Novak J, Gandley RE, Johnston TP, McLaughlin MK, Hubel CA. Endothelial function and myogenic reactivity in small mesenteric arteries of hyperlipidemic pregnant rats. Am J Physiol, 281:1330-1337, 2001.
Bilodeau J-F, Hubel CA. Current concepts in the use of antioxidants for the treatment of preeclampsia. (Invited review.) Can J Obstet Gynecol, 25(9):742-750, 2003.
Hubel CA, Bodnar LM, Many A, Harger G, Ness RB, Roberts JM. Non-glycosylated ferritin predominates in serum of women with preeclampsia but not in intrauterine growth restriction. Clin Chem, 50(5):948-951, 2004.
Hubel CA, Wolf M, Lam C, Sampson M, Ecker JL, Ness RB, Rajakumar A, Daftary A, Shakir ASM, Seely EW, Roberts JM, Sukhatme VK, Karumanchi SA, Thadhani R. Preeclampsia and future cardiovascular disease: Potential role of altered angiogenesis and insulin resistance. J Clin Endocrinol Metab, 89:6239-6243, 2004.
Shibata E, Rajakumar A, Powers RW, Larkin RW, Gilmour C, Crombleholme WR, Ness RB, Roberts JM, Hubel CA. Soluble fms-like tyrosine kinase 1 (sFlt-1) is increased in preeclampsia but not in small for gestational age pregnancies: Relationship to circulating placental growth factor (PlGF). J Clin Endocrinol Metab, 26:4895-4903, 2005.
Professional Affiliations
Society for Gynecologic Investigation
International Society for the Study of Hypertension in Pregnancy
North American Society for the Study of Hypertension in Pregnancy
Society for Free Radical Biology and Medicine
Contact Information
Magee-Womens Research Institute
204 Craft Avenue
Pittsburgh, PA 15213
Telephone: 412-641-6130
Fax: 412-641-1503
E-mail: chubel@mwri.magee.edu
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